研究業績

Takamasa Gomi, Toru Imamura: Age-related changes in the vasculature of the dermis of the upper lip vermilion. Aging (Albany NY). 06/2019; 11(11): 3551–3560. DOI:10.18632/aging.101996

Ryuji Yamada, Riona Fukumoto, Chisato Noyama, Akio Fujisawa, Syuichi Oka, Toru Imamura: An epidermis-permeable dipeptide is a potential cosmetic ingredient with partial agonist/antagonist activity toward fibroblast growth factor receptors. Journal of Cosmetic Dermatology 04/2019; 17(5). DOI:10.1111/jocd.12997

Mitsuko Kawano, Taichi Miura, Mayumi Fujita, Sachiko Koike, Kaori Imadome, Atsuko Ishikawa, Takeshi Yasuda, Toru Imamura, Takashi Imai, Fumiaki Nakayama: The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma. Clinical and Translational Radiation Oncology 01/2019; 14: 8-16, DOI:10.1016/j.ctro.2018.10.004

Jun Hosogi, Rui Ohashi, Hiroshi Maeda, Kazuhiro Fujita, Junko Ushiki, Takashi Kuwabara, Yorihiro Yamamoto, Toru Imamura: An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: Irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins. Biopharmaceutics & Drug Disposition 02/2018; 39(3)., DOI:10.1002/bdd.2123

Mei Shigematsu, Shozo Tomonaga, Fumie Shimokawa, Masaru Murakami, Toru Imamura, Tohru Matsui, Masayuki Funaba: Regulatory responses of hepatocytes, macrophages and vascular endothelial cells to magnesium deficiency. The Journal of Nutritional Biochemistry 02/2018; 56., DOI:10.1016/j.jnutbio.2018.01.008

Taichi Miura, Mayumi Fujita, Mitsuko Kawano, Kaori Imadome, Takeshi Yasuda, Shoko Nishihara, Toru Imamura, Mikio Masuzawa, Takashi Imai, Fumiaki Nakayama: Strong radioprotective FGF1 signaling down-regulates proliferative and metastatic capabilities of the angiosarcoma cell line, ISOS-1, through the dual inhibition of EGFR and VEGFR pathways. 11/2017; 7., DOI:10.1016/j.ctro.2017.10.006

Kouhei Ito, Ryuji Yamada, Nobuki Matsumoto, Toru Imamura: Evaluation of fibroblast growth factor activity exerted by placental extract used as a cosmetic ingredient. Journal of Cosmetic Dermatology 10/2017; 17(5)., DOI:10.1111/jocd.12434

Mitsuko Kawano, Sachiko Umeda, Takashi Yasuda, Toru Imamura, Takashi Imai, Fumiaki Nakayama: FGF18 maintains hair follicle stem cells after radiation exposure. Journal of Dermatological Science 10/2016; 84(1):e155., DOI:10.1016/j.jdermsci.2016.08.460

Fumiaki Nakayama, Sachiko Umeda, Takashi Yasuda, Toru Imamura, Takashi Imai: FGF signaling for hair cycle resting phase alleviates radiation alopecia. Journal of Dermatological Science 10/2016; 84(1):e58., DOI:10.1016/j.jdermsci.2016.08.180

Fumiaki Nakayama, Sachiko Umeda, Takashi Yasuda, Mitsuko Kawano, Mayumi Fujita, Atsuko Ishikawa, Toru Imamura, Takashi Imai: FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling. Journal of Dermatological Science 10/2016; 84(1):e154., DOI:10.1016/j.jdermsci.2016.08.459

Mitsuko Kawano, Sachiko Umeda, Takeshi Yasuda, Mayumi Fujita, Atsuko Ishikawa, Toru Imamura, Takashi Imai, Fumiaki Nakayama: FGF18 Signaling in the Hair Cycle Resting Phase Determines Radioresistance of Hair Follicles by Arresting Hair Cycling. 06/2016; 1(3)., DOI:10.1016/j.adro.2016.05.004

Bisser Raytchev, Atsuki Masuda, Masatoshi Minakawa, Kojiro Tanaka, Takio Kurita, Toru Imamura, Masashi Suzuki, Toru Tamaki, Kazufumi Kaneda: Detection of Differentiated vs. Undifferentiated Colonies of iPS Cells Using Random Forests Modeled with the Multivariate Polya Distribution. International Conference on Medical Image Computing and Computer-Assisted Intervention; 10/2016, DOI:10.1007/978-3-319-46723-8_77

Tatsuo Maeda, Toshiyuki Yamamoto, Toru Imamura, Ryoji Tsuboi: Impaired wound healing in bleomycin-induced murine scleroderma: a new model of wound retardation. Archives for Dermatological Research 12/2015; 308(2)., DOI:10.1007/s00403-015-1614-7

Toru Imamura: Fgf System and Gags. DOI:10.1007/978-4-431-54841-6_57

Tomoko Okada, Mutsuo Furihata, Atsushi Kurabayashi, Toru Imamura: Abstract 2253: Cadherin 17 plays an important role in breast cancer metastasis to bone marrow. Cancer Research 08/2015; 75(15 Supplement):2253-2253., DOI:10.1158/1538-7445.AM2015-2253

Yasuko Onuma, Kumiko Higuchi, Yasuhiko Aiki, Yujing Shu, Masahiro Asada, Makoto Asashima, Masashi Suzuki, Toru Imamura, Yuzuru Ito: A Stable Chimeric Fibroblast Growth Factor (FGF) Can Successfully Replace Basic FGF in Human Pluripotent Stem Cell Culture. PLoS ONE 04/2015; 10(4):e0118931., DOI:10.1371/journal.pone.0118931

Atsuki Masuda, Bisser Raytchev, Takio Kurita, Toru Imamura, Masashi Suzuki, Toru Tamaki, Kazufumi Kaneda: Automatic Detection of Good/Bad Colonies of iPS Cells Using Local Features. International Workshop on Machine Learning in Medical Imaging; 10/2015, DOI:10.1007/978-3-319-24888-2_19

T. Imamura: Development of a stable growth factor suitable for radioprotection – Drug development-aimed R&D at a basic research institute. Synthesiology 12/2014; 7(3):140-153.

Toru Imamura: Development of a stable growth factor suitable for radioprotection. Synthesiology (J) 12/2014; 7(3):140-153.12/2014; 7(3):134-148., DOI:10.5571/syntheng.7.134

Toru Imamura: Physiological Functions and Underlying Mechanisms of Fibroblast Growth Factor (FGF) Family Members: Recent Findings and Implications for Their Pharmacological Application. Biological & Pharmaceutical Bulletin 07/2014; 37(7):1081-9., DOI:10.1248/bpb.b14-00265

Fumiaki Nakayama, Sachiko Umeda, Takeshi Yasuda, Mayumi Fujita, Masahiro Asada, Viktor Meineke, Toru Imamura, Takashi Imai: Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling. International journal of radiation oncology, biology, physics 12/2013; 88(2)., DOI:10.1016/j.ijrobp.2013.10.035

Tomoko Okada, Kazuhiro Murata, Ryoma Hirose, Chie Matsuda, Tsunehiko Komatsu, Masahiko Ikekita, Miyako Nakawatari, Fumiaki Nakayama, Masaru Wakatsuki, Tatsuya Ohno, Shingo Kato, Takashi Imai, Toru Imamura: Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells. Scientific Reports 10/2013; 3:2899., DOI:10.1038/srep02899

C. Matsuda, K. Miyake, T. Imamura, N. Araki, I. Nishino, Y.K. Hayashi: P.5.1 Sarcolemmal repair and reorganization of microtubule. Neuromuscular Disorders 10/2013; 23(9-10):764., DOI:10.1016/j.nmd.2013.06.453

Naoko Nagai, Hiroko Habuchi, Noriko Sugaya, Masao Nakamura, Toru Imamura, Hideto Watanabe, Koji Kimata: Involvement of heparan sulfate 6-O-sulfation in regulation of energy metabolism and alteration of thyroid hormone levels in male mice.. Glycobiology 05/2013; 23(8)., DOI:10.1093/glycob/cwt037

Fumiaki Nakayama, Sachiko Umeda, Masahiro Asada, Toru Imamura, Takashi Imai: FGF chimeric growth factor (FGFC) promoted hair regeneration after radiation damage. Journal of Dermatological Science 02/2013; 69(2):e61., DOI:10.1016/j.jdermsci.2012.11.488

Toru Imamura, Yuko Oda, Junko Oki, Akiko Komi-Kuramochi, Emi Honda, Masahiro Asada, Masashi Suzuki, Miho Kimura-Ueki: Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling. Journal of Dermatological Science 02/2013; 69(2):e64-e65., DOI:10.1016/j.jdermsci.2012.11.499

Naomi J Bisem, Shigeko Takeuchi, Toru Imamura, Essam M Abdelalim, Ikuo Tooyama: Mapping of FGF1 in the Medulla Oblongata of Macaca fascicularis. Acta histochemica et cytochemica official journal of the Japan Society of Histochemistry and Cytochemistry 12/2012; 45(6):325-34., DOI:10.1267/ahc.12021

Chie Matsuda, Katsuya Miyake, Kimihiko Kameyama, Etsuko Keduka, Hiroshi Takeshima, Toru Imamura, Nobukazu Araki, Ichizo Nishino, Yukiko Hayashi: The C2A domain in dysferlin is important for association with MG53 (TRIM72). PLoS Currents 11/2012; 4:e5035add8caff4., DOI:10.1371/5035add8caff4

Masao Nakamura, Yuriko Uehara, Masahiro Asada, Masashi Suzuki, Toru Imamura: Sulfated Glycosaminoglycan-Assisted Receptor Specificity of Human Fibroblast Growth Factor (FGF) 19 Signaling in a Mouse System Is Different from That in a Human System. Journal of Biomolecular Screening 10/2012; 18(3)., DOI:10.1177/1087057112463820

Fumiaki Nakayama, Sachiko Umeda, Takeshi Yasuda, Masahiro Asada, Kaori Motomura, Masashi Suzuki, Malgorzata Zakrzewska, Toru Imamura, Takashi Imai: Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage. International journal of radiation oncology, biology, physics 06/2012; 85(2)., DOI:10.1016/j.ijrobp.2012.04.042

Hirofumi Sakai, Mutsuo Furihata, Chie Matsuda, Munehisa Takahashi, Hiroshi Miyazaki, Takeo Konakahara, Toru Imamura, Tomoko Okada: Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells. Clinical and Experimental Metastasis 04/2012; 29(4):327-38., DOI:10.1007/s10585-012-9453-9

Miho Kimura-Ueki, Yuko Oda, Junko Oki, Akiko Komi-Kuramochi, Emi Honda, Masahiro Asada, Masashi Suzuki, Toru Imamura: Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling. Journal of Investigative Dermatology 02/2012; 132(5):1338-45., DOI:10.1038/jid.2011.490

Fumiaki Nakayama, Takeshi Yasuda, Sachiko Umeda, Masahiro Asada, Toru Imamura, Viktor Meineke, Makoto Akashi: Fibroblast Growth Factor-12 (FGF12) Translocation into Intestinal Epithelial Cells Is Dependent on a Novel Cell-penetrating Peptide Domain. Journal of Biological Chemistry 07/2011; 286(29):25823-25834.

Yuichiro Miyaoka, Hidenori Kato, Kazuki Ebato, Shigeru Saito, Naoko Miyata, Toru Imamura, Atsushi Miyajima: Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms. Biochemical Journal 07/2011; 440(1):33-41., DOI:10.1042/BJ20110318

Masao Nakamura, Yuriko Uehara, Masahiro Asada, Emi Honda, Naoko Nagai, Koji Kimata, Masashi Suzuki, Toru Imamura: Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling via FGF Receptor 4 and betaKlotho. Journal of Biological Chemistry 06/2011; 286(30):26418-23., DOI:10.1074/jbc.M111.251140

Fumiaki Nakayama, Takeshi Yasuda, Sachiko Umeda, Masahiro Asada, Toru Imamura, Viktor Meineke, Makoto Akashi: Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: Involvement of internalization in the in vivo role of exogenous FGF12. Journal of Biological Chemistry 04/2011; 286(29):25823-34., DOI:10.1074/jbc.M110.198267

Fumiaki Nakayama, Akiko Hagiwara, Sachiko Umeda, Masahiro Asada, Megumi Goto, Junko Oki, Masashi Suzuki, Toru Imamura, Makoto Akashi: Post Treatment With an FGF Chimeric Growth Factor Enhances Epithelial Cell Proliferation to Improve Recovery From Radiation-Induced Intestinal Damage. International journal of radiation oncology, biology, physics 11/2010; 78(3):860-7., DOI:10.1016/j.ijrobp.2010.04.045

Yuichiro Miyaoka, Minoru Tanaka, Toru Imamura, Shinji Takada, Atsushi Miyajima: A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk). Development 01/2010; 137(1):159-67., DOI:10.1242/dev.041574

T. Imamura: Glycoengineering of FGF proteins. AIST TODAY 2009-Winter; 12.

Masashi Suzuki, Toru Imamura: [Signaling of metabolic regulatory FGFs: specificity determination by co-receptors]. Seikagaku. The Journal of Japanese Biochemical Society 08/2009; 81(7):592-7.

Akiko Hagiwara, Fumiaki Nakayama, Kaori Motomura, Masahiro Asada, Masashi Suzuki, Toru Imamura, Makoto Akashi: Comparison of Expression Profiles of Several Fibroblast Growth Factor Receptors in the Mouse Jejunum: Suggestive Evidence for a Differential Radioprotective Effect among Major FGF Family Members and the Potency of FGF1. Radiation Research 08/2009; 172(1):58-65., DOI:10.1667/RR1570.1

Kurashige, Y. Oda, T. Imamura, R. Tsuboi: Localization of fibroblast growth factor (FGF)-7 family protein in full-thickness skin wounds. 創傷治癒過程における fibroblast growth factor (FGF)-7 ファミリー蛋白の局在. 東京醫科大學雜誌, 2009; 67(2), 176-183, 2009-04-30

Fumiaki Nakayama, Akiko Hagiwara, Miho Kimura, Makoto Akashi, Toru Imamura: Evaluation of radiation-induced hair follicle apoptosis in mice and the preventive effects of fibroblast growth factor-1. Experimental Dermatology 04/2009; 18(10):889-92., DOI:10.1111/j.1600-0625.2009.00849.x

Masahiro Asada, Michiyo Shinomiya, Masashi Suzuki, Emi Honda, Rika Sugimoto, Masahiko Ikekita, Toru Imamura: Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochimica et Biophysica Acta 10/2008; 1790(1):40-8., DOI:10.1016/j.bbagen.2008.09.001

Kaori Motomura, Akiko Hagiwara, Akiko Komi-Kuramochi, Yoshiro Hanyu, Emi Honda, Masashi Suzuki, Miho Kimura, Junko Oki, Masahiro Asada, Nagako Sakaguchi, Fumiaki Nakayama, Makoto Akashi, Toru Imamura: An FGF1:FGF2 chimeric growth factor exhibits universal FGF receptor specificity, enhanced stability and augmented activity useful for epithelial proliferation and radioprotection. Biochimica et Biophysica Acta 09/2008; 1780(12):1432-40., DOI:10.1016/j.bbagen.2008.08.001

Masashi Suzuki, Yuriko Uehara, Kaori Motomura-Matsuzaka, Junko Oki, Yoshinori Koyama, Miho Kimura, Masahiro Asada, Akiko Komi-Kuramochi, Syuichi Oka, Toru Imamura: BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Molecular Endocrinology 05/2008; 22(4):1006-14., DOI:10.1210/me.2007-0313

Masahiro Asada, Emi Honda, Toru Imamura: Biologically active fibroblast growth factor 1 tagged with various epitopes. BMC Research Notes 02/2008; 1(1):42., DOI:10.1186/1756-0500-1-42

A Saito, H Okano, H Bamba, Y Hisa, Y Oomura, T Imamura, I Tooyama: Low expression of FGF1 (Fibroblast growth factor-1) in rat parasympathetic preganglionic neurons. Histology and histopathology 01/2008; 22(12):1327-35., DOI:10.14670/HH-22.1327

Ken Nishimura, Hiroaki Segawa, Takahiro Goto, Mariko Morishita, Akinori Masago, Hitoshi Takahashi, Yoshihiro Ohmiya, Takemasa Sakaguchi, Masahiro Asada, Toru Imamura, Kunitada Shimotono, Kozo Takayama, Tetsuya Yoshida, Mahito Nakanishi: Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus. Journal of Biological Chemistry 10/2007; 282(37):27383-91., DOI:10.1074/jbc.M702028200

Hiroyuki Okano, Ken-ichiro Toyoda, Hitoshi Bamba, Yasuo Hisa, Yutaka Oomura, Toru Imamura, Shoei Furukawa, Hiroshi Kimura, Ikuo Tooyama: Localization of Fibroblast Growth Factor-1 in Cholinergic Neurons Innervating the Rat Larynx. Journal of Histochemistry and Cytochemistry 10/2006; 54(9):1061-71., DOI:10.1369/jhc.5A6843.2006

Masahiro Asada, Emi Honda, Toru Imamura: Construction of pcDNA3.1-based vectors with blasticidin and puromycin resistance markers. Analytical Biochemistry 06/2006; 352(2):305-7., DOI:10.1016/j.ab.2006.03.017

Ken-Ichiro Toyoda, Hiroyuki Okano, Hitoshi Bamba, Yasuo Hisa, Yutaka Oomura, Toru Imamura, Shoei Furukawa, Ikuo Tooyama: Comparison of FGF1 (aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat. Acta histochemica et cytochemica official journal of the Japan Society of Histochemistry and Cytochemistry 03/2006; 39(1):1-7., DOI:10.1267/ahc.05047

Akiko Komi-Kuramochi, Mitsuko Kawano, Yuko Oda, Masahiro Asada, Masashi Suzuki, Junko Oki, Toru Imamura: Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. Journal of Endocrinology 09/2005; 186(2):273-89., DOI:10.1677/joe.1.06055

Mitsuko Kawano, Akiko Komi-Kuramochi, Masahiro Asada, Masashi Suzuki, Junko Oki, Ju Jiang, Toru Imamura: Comprehensive Analysis of FGF and FGFR Expression in Skin: FGF18 Is Highly Expressed in Hair Follicles and Capable of Inducing Anagen from Telogen Stage Hair Follicles. Journal of Investigative Dermatology 06/2005; 124(5):877-85., DOI:10.1111/j.0022-202X.2005.23693.x

Akira Ishisaki, Hironaka Tsunobuchi, Keiichi Nakajima, Toru Imamura: Possible involvement of protein kinase C activation in differentiation of human umbilical vein endothelium-derived cell into smooth muscle-like cell. Biology of the Cell 10/2004; 96(7):499-508., DOI:10.1016/j.biolcel.2004.04.012

Mitsuko Kawano, Satoshi Suzuki, Masashi Suzuki, Junko Oki, Toru Imamura: Bulge- and Basal Layer-Specific Expression of Fibroblast Growth Factor-13 (FHF-2) in Mouse Skin. Journal of Investigative Dermatology 06/2004; 122(5):1084-90., DOI:10.1111/j.0022-202X.2004.22514.x

Hironaka Tsunobuchi, Akira Ishisaki, Toru Imamura: Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells. Biochemical and Biophysical Research Communications 05/2004; 316(3):712-9., DOI:10.1016/j.bbrc.2004.02.104

Chikako Ito, Yuko Saitoh, Yasuko Fujita, Yoshimitsu Yamazaki, Toru Imamura, Syuichi Oka, Satoshi Suzuki: Decapeptide with Fibroblast Growth Factor (FGF)-5 Partial Sequence Inhibits Hair Growth Suppressing Activity of FGF-5. Journal of Cellular Physiology 11/2003; 197(2):272-83., DOI:10.1002/jcp.10369

Kazuko Miyakawa, Toru Imamura: Secretion of FGF-16 Requires an Uncleaved Bipartite Signal Sequence. Journal of Biological Chemistry 10/2003; 278(37):35718-24., DOI:10.1074/jbc.M300690200

Ai-Jun Li, Masashi Suzuki, Seigo Suzuki, Mitsushi Ikemoto, Toru Imamura: Differential phosphorylation at serine sites in glutamate receptor-1 within neonatal rat hippocampus. Neuroscience Letters 05/2003; 341(1):41-4., DOI:10.1016/S0304-3940(03)00157-5

Akiko Komi, Akira Ishisaki, Masashi Suzuki, Toru Imamura: A permeable FGF-1 nuclear localization sequence peptide induces DNA synthesis independently of Ras activation. Experimental Cell Research 03/2003; 283(1):91-100., DOI:10.1016/S0014-4827(02)00029-0

Hisaki Hayashi, Akira Ishisaki, Toru Imamura: Hayashi H, Ishisaki A and Imamura TSmad mediates BMP-2-induced upregulation of FGF-evoked PC12 cell differentiation. FEBS Lett. 11: 30-34. FEBS Letters 03/2003; 536(1-3):30-4., DOI:10.1016/S0014-5793(03)00005-X

Takashi Sato, Masanori Gotoh, Katsue Kiyohara, Tomohiro Akashima, Hiroko Iwasaki, Akihiko Kameyama, Hideo Mochizuki, Toshikazu Yada, Niro Inaba, Akira Togayachi, Takashi Kudo, Masahiro Asada, Hideto Watanabe, Toru Imamura, Koji Kimata, Hisashi Narimatsu: Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2 – Initiation and elongation in synthesis of chondroitin sulfate. Journal of Biological Chemistry 02/2003; 278(5):3063-71., DOI:10.1074/jbc.M208886200

Masahiro Asada, Toru Imamura: Strategy for Construction of a cDNA Encoding a Repetitive Amino Acid Sequence. Methods in Molecular Biology 02/2003; 221:261-9., DOI:10.1385/1-59259-359-3:261

Akira Ishisaki, Hisaki Hayashi, Ai-Jun Li, Toru Imamura: Human Umbilical Vein Endothelium-derived Cells Retain Potential to Differentiate into Smooth Muscle-like Cells. Journal of Biological Chemistry 02/2003; 278(2):1303-9., DOI:10.1074/jbc.M207329200

S Aou, X-L Li, A-J Li, Y Oomura, T Shiraishi, K Sasaki, T Imamura, M.J. Wayner: Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats. Neuroscience 02/2003; 119(4):1221-8., DOI:10.1016/S0306-4522(02)00745-5

Mitsushi J Ikemoto, Koutarou Inoue, Saori Akiduki, Takeshi Osugi, Toru Imamura, Norio Ishida, Michiko Ohtomi: Identification of addicsin/GTRAP3-18 as a chronic morphine-augmented gene in amygdala. Neuroreport 12/2002; 13(16):2079-84., DOI:10.1097/00001756-200211150-00018

Ai-Jun Li, Seigo Suzuki, Masashi Suzuki, Eiichi Mizukoshi, Toru Imamura: Fibroblast growth factor-2 increases functional excitatory synapses on hippocampal neurons. European Journal of Neuroscience 11/2002; 16(7):1313-24., DOI:10.1046/j.1460-9568.2002.02193.x

Seigo Suzuki, Ai-Jun Li, Mitsushi Ikemoto, Toru Imamura: Expression of tenascin-C long isoforms is induced in the hypothalamus by FGF-I. Neuroreport 07/2002; 13(8):1041-5., DOI:10.1097/00001756-200206120-00013

Yutaka Ota, Yuko Saitoh, Satoshi Suzuki, Kazuo Ozawa, Mitsuko Kawano, Toru Imamura: Fibroblast Growth Factor 5 Inhibits Hair Growth by Blocking Dermal Papilla Cell Activation. Biochemical and Biophysical Research Communications 02/2002; 290(1):169-76., DOI:10.1006/bbrc.2001.6140

M Kawano, K Kawasaki, A Yoneda, M Asada, T Imamura, H Miyamoto: Analysis of influenza virus-sugar chain interaction by single virion imaging.. Seibutsu Butsuri 09/2001; 41(supplement):S136., DOI:10.2142/biophys.41.S136_4

Masahiro Asada, Atsuko Yoneda, Toru Imamura: Engineering of a Heparin-Binding Growth Factor with Heparan Sulfate Sugar Chains. Trends in Glycoscience and Glycotechnology 07/2001; 13(72):385-394., DOI:10.4052/tigg.13.385

Akira Ishisaki, Hisaki Hayashi, Seigo Suzuki, Kazuo Ozawa, Eiichi Mizukoshi, Kazuko Miyakawa, Masashi Suzuki, Toru Imamura: Glutathione S-transferase Pi is a dopamine-inducible suppressor of dopamine-induced apoptosis in PC12 cells. Journal of Neurochemistry 07/2001; 77(5):1362-71., DOI:10.1046/j.1471-4159.2001.00351.x

S Suzuki, A J Li, A Ishisaki, X Hou, M Hasegawa, M Fukumura, T Akaike, T Imamura: Feeding suppression by fibroblast growth factor-1 is accompanied by selective induction of heat shock protein 27 in hypothalamic astrocytes. European Journal of Neuroscience 07/2001; 13(12):2299-308.

Seigo Suzuki, Ai-Jun Li, Akira Ishisaki, Xiaogang Hou, Mamoru Hasegawa, Masayuki Fukumura, Toshihiro Akaike, Toru Imamura: Feeding suppression by fibroblast growth factor‐1 is accompanied by selective induction of heat shock protein 27 in hypothalamic astrocytes. European Journal of Neuroscience 06/2001; 13(12):2299 – 2308., DOI:10.1046/j.0953-816x.2001.01606.x

H Hayashi, A Ishisaki, M Suzuki, T Imamura: BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression. Journal of Cell Science 05/2001; 114(Pt 7):1387-95.

Atsuko Yoneda, Masahiro Asada, Saori Yamamoto, Junko Oki, Yuko Oda, Keiko Ota, Yoko Ogi, Sachi Fujishima, Toru Imamura: Engineering neoglycoproteins with multiple O-glycans using repetitive pentapeptide glycosylation units. Glycoconjugate Journal 05/2001; 18(4):291-9., DOI:10.1023/A:1013608930759

Seigo Suzuki, A J Li, Toshihiro Akaike, Toru Imamura: Intracerebroventricular infusion of fibroblast growth factor-1 increases Fos immunoreactivity in periventricular astrocytes in rat hypothalamus. Neuroscience Letters 04/2001; 300(1):29-32., DOI:10.1016/S0304-3940(01)01535-X

Eiichi Mizukoshi, Masashi Suzuki, Tomoko Misono, Alexei Loupatov, Eisuke Munekata, Sunil C. Kaul, Renu Wadhwa, Toru Imamura: Cell-Cycle Dependent Tyrosine Phosphorylation on Mortalin Regulates Its Interaction with Fibroblast Growth Factor-1. Biochemical and Biophysical Research Communications 03/2001; 280(4):1203-9., DOI:10.1006/bbrc.2001.4225

A.B McGeachie, K Koishi, T Imamura, I S McLennan: Fibroblast growth factor-5 is expressed in Schwann cells and is not essential for motoneurone survival. Neuroscience 02/2001; 104(3):891-9., DOI:10.1016/S0306-4522(01)00129-4

Satoshi Suzuki, Yutaka Ota, Kazuo Ozawa, Toru Imamura: Controlling Fibroblast Growth Factors for Hair Growth Regulation.. 01/2001; 35(3):231-236., DOI:10.5107/sccj.35.3_231

Masahiro Asada, Atsuko Yoneda, Yuko Oda, Toru Imamura: Construction of a cDNA Encoding a Repetitive Amino Acid Sequence. BioTechniques 12/2000; 29(5):978, 981., DOI:10.2144/00295bm10

M Asada, A Yoneda, Y Oda, T Imamura: Construction of a cDNA encoding an acceptor sequence for clustered O-glycan. Glycobiology 10/2000; 10(10):1103-1103.

Mitsushi Ikemoto, Masatoshi Takita, Toru Imamura, Koutarou Inoue: Increased sensitivity to the stimulant effect of morphine conferred by anti-adhesive glycoprotein SPARC in amygdala. Nature Medicine 09/2000; 6(8):910-5., DOI:10.1038/78675

Atsuko Yoneda, Masahiro Asada, Yuko Oda, Masashi Suzuki, Toru Imamura: Engineering of an FGF-proteoglycan fusion protein with heparin-independent, mitogenic activity. Nature Biotechnology 07/2000; 18(6):641-4., DOI:10.1038/76487

Satoshi Suzuki, Yutaka Ota, Kazuo Ozawa, Toru Imamura: Dual-Mode Regulation of Hair Growth Cycle by Two Fgf-5 Gene Products. Journal of Investigative Dermatology 04/2000; 114(3):456-63., DOI:10.1046/j.1523-1747.2000.00912.x

Hisaki Hayashi, Atsuko Yoneda, Masahiro Asada, Masahiko Ikekita, Toru Imamura: Molecular Cloning of Mouse Alpha-1,6-Fucosyltransferase and Expression of Its mRNA in the Developing Cerebrum. DNA Sequence 02/2000; 11(1-2):91-6., DOI:10.3109/10425170009033974

K Miyakawa, K Hatsuzawa, T Kurokawa, M Asada, T Kuroiwa, T Imamura: A Hydrophobic Region Locating at the Center of Fibroblast Growth Factor-9 Is Crucial for Its Secretion. Journal of Biological Chemistry 11/1999; 274(41):29352-7., DOI:10.1074/jbc.274.41.29352

Eiichi Mizukoshi, Masashi Suzuki, Alexei Loupatov, Takehito Uruno, Hisaki Hayashi, Tomoko Misono, Sunil C. Kaul, Renu Wadhwa, Toru Imamura: Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. Biochemical Journal 11/1999; 343 Pt 2(Pt 2):461-6., DOI:10.1042/0264-6021:3430461

Atsuko Yoneda, Masahiro Asada, Masashi Suzuki, Toru Imamura: Introduction of an N -Glycosylation Cassette into Proteins at Random Sites: Expression of Neoglycosylated FGF. BioTechniques 10/1999; 27(3):576-8, 580, 582 passim., DOI:10.2144/99273rr05

Masahiro Asada, Noriko Orikasa, Atsuko Yoneda, Yuko Oda, Keiko Ota, Toru Imamura: The AATPAP sequence is a very efficient signal for O-glycosylation in CHO cells. Glycoconjugate Journal 08/1999; 16(7):321-6., DOI:10.1023/A:1007092708666

Ai‐Jun Li, Kazuo Ozawa, Hiroyuki Tsuboyama, Toru Imamura: Distribution of fibroblast growth factor-5 in rat hypothalamus, and its possible role as a regulator of feeding behaviour. European Journal of Neuroscience 05/1999; 11(4):1362-8., DOI:10.1046/j.1460-9568.1999.00546.x

Kazuko Miyakawa, Kazuo Ozawa, Takehito Uruno, Toru Imamura: The C-terminal Region of Fibroblast Growth Factor-1 is Crucial for its Biological Activity and High Level Protein Expression in Mammalian Cells. Growth Factors 02/1999; 16(3):191-200., DOI:10.3109/08977199909002129

Masahiro Asada, Atsuko Yoneda, Yuko Oda, Keiko Ota, Kazuo Ozawa, Kazuhiro Fukuta, Fumio Omae, Mineko Asanagi, Noriko Orikasa, Masashi Suzuki, Syuichi Oka, Tadashi Makino, Toru Imamura: Characterization of Fibroblast Growth Factor-6 Expressed by Chinese Hamster Ovary Cells as a Glycosylated Mitogen for Human Vascular Endothelial Cells. Growth Factors 02/1999; 16(4):293-303., DOI:10.3109/08977199909069147

Takehito Uruno, Junko Oki, Kazuo Ozawa, Kazuko Miyakawa, Hikaru Ueno, Toru Imamura: Distinct Regulation of Myoblast Differentiation by Intracellular and Extracellular Fibroblast Growth Factor-1. Growth Factors 02/1999; 17(2):93-113., DOI:10.3109/08977199909103519

Satoshi Suzuki, Tomomi Kato, Hiroyuki Takimoto, Shigeki Masui, Hiroshi Oshima, Kazuo Ozawa, Toru Imamura: Localization of Rat FGF-5 Protein in Skin Macrophage-like Cells and FGF-5S Protein in Hair Follicle: Possible Involvement of two Fgf-5 Gene Products in Hair Growth Cycle Regulation. Journal of Investigative Dermatology 01/1999; 111(6):963-72., DOI:10.1046/j.1523-1747.1998.00427.x

K Ozawa, S Suzuki, M Asada, Y Tomooka, AJ Li, A Yoneda, A Komi, T Imamura: An Alternatively Spliced Fibroblast Growth Factor (FGF)-5 mRNA Is Abundant in Brain and Translates into a Partial Agonist/Antagonist for FGF-5 Neurotrophic Activity. Journal of Biological Chemistry 11/1998; 273(44):29262-71., DOI:10.1074/jbc.273.44.29262

AJ Li, Hiroyuki Tsuboyama, Akiko Komi, Masahiko Ikekita, Toru Imamura: Strong suppression of feeding by a peptide containing both the nuclear localization sequence of fibroblast growth factor-1 and a cell membrane-permeable sequence. Neuroscience Letters 11/1998; 255(1):41-4., DOI:10.1016/S0304-3940(98)00701-0

Akiko Komi, Masashi Suzuki, Toru Imamura: Permeable FGF-1 Nuclear Localization Signal Peptide Stimulates DNA Synthesis in Various Cell Types but Is Cell-Density Sensitive and Unable to Support Cell Proliferation. Experimental Cell Research 10/1998; 243(2):408-14., DOI:10.1006/excr.1998.4176

T Uruno, A Komi, T Imamura: Progress of signal transduction research for fibroblast growth factors. Seikagaku. The Journal of Japanese Biochemical Society 07/1998; 70(6):446-53.

M Suzuki, G Raab, MA Moses, C Fernandez, T Imamura, M Klagsbrun: Release of active heparin-binding EGF-like growth factor by matrix metalloproteinase-3. Molecular Biology of the Cell 11/1997; 8:47-47.

Kazuo Ozawa, Misuzu Seo, Toru Imamura: A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR. Brain Research Protocols 09/1997; 1(3):211-6., DOI:10.1016/S1385-299X(96)00030-X

Kazuo Ozawa, Takehito Uruno, Kazuko Miyakawa, Misuzu Seo, Toru Imamura: Expression of the fibroblast growth factor family and their receptor family genes during mouse development. Molecular Brain Research 10/1996; 41(1-2):279-88., DOI:10.1016/0169-328X(96)00108-8

T Tanahashi, M Suzuki, T Imamura, Y Mitsui: Identification of a 79-kDa heparin-binding fibroblast growth factor (FGF) receptor in rat hepatocytes and its correlation with the different growth responses to FGF-1 between hepatocyte subpopulations. Journal of Biological Chemistry 05/1996; 271(14):8221-7., DOI:10.1074/jbc.271.14.8221

T Imamura, T Tanahashi: A novel chimeric fibroblast growth factor for liver parenchymal cells. Hepatology 03/1996; 23(2):316-9., DOI:10.1053/jhep.1996.v23.pm0008591858

Toru Imamura, Stanley A. Friedman, Susan Gamble, Yoshihito Tokita, Susan R. Opalenik, John A. Thompson, Thomas Maciag: Identification of the domain within fibroblast growth factor-1 responsible for heparin-dependence. Biochimica et Biophysica Acta 04/1995; 1266(2):124-30., DOI:10.1016/0167-4889(95)00009-H

Toru Imamura, Syuichi Oka, Tadanori Tanahashi, Yukiko Okita: Cell Cycle-Dependent Nuclear Localization of Exogenously Added Fibroblast Growth Factor-1 in BALB/c 3T3 and Human Vascular Endothelial Cells. Experimental Cell Research 01/1995; 215(2):363-72., DOI:10.1006/excr.1994.1353

Tadanori Tanahashi, Masashi Suzuki, Toru Imamura, Youji Mitsui: Re-evaluation of FGF-1 as a potent mitogen for hepatocytes. In Vitro Cellular & Developmental Biology – Animal 03/1994; 30(3):139-141., DOI:10.1007/BF02631434

T Imamura, Y Tokita, Y Mitsui: Identification of a heparin-binding growth factor-1 nuclear translocation sequence by deletion mutation analysis. Journal of Biological Chemistry 04/1992; 267(8):5676-9.

Reza Forough, Kurt Engleka, John A. Thompson, Anthony Jackson, Toru Imamura, Thomas Maciag: Differential expression in Escherichia coli of the alpha and beta forms of heparin-binding acidic fibroblast growth factor-1: Potential role of RNA secondary structure. Biochimica et Biophysica Acta 12/1991; 1090(3):293-8., DOI:10.1016/0167-4781(91)90192-O

Youji Mitsui, Kaname Saida, Norio Ishida, Toru Imamura, Mieko Kobayashi: Establishment of vascular endothelial cell lines in a serum-free culture and the discovery of endothelin and a Vasoactive Intestinal Contractor (VIC). Cytotechnology 11/1991; 5:9-16., DOI:10.1007/BF00573877

Toru Imamura, Yoshihito Tokita, Youji Mitsui: Contact with Basement Membrane Heparan Sulfate Enhances the Growth of Transformed Vascular Endothelial Cells, but Suppresses Normal Cells.. Cell Structure and Function 07/1991; 16(3):225-30., DOI:10.1247/csf.16.225

Y Mitsui, T Imamura: [Growth regulation of vascular cells by FGFs and a novel ECGF]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 06/1991; 36(7):1237-46.

T Imamura, K Engleka, X. I. Zhan, Y Tokita, R Forough, D Roeder, A Jackson, J.A.M. Maier, T Hla, T Maciag: Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence. Science 10/1990; 249(4976):1567-70., DOI:10.1126/science.1699274

Nobuhiko Hasegawa, Mari Yamamoto, Toru Imamura, Youji Mitsui, Kiyotaka Yamamoto: Evaluation of long-term culture endothelial cells as a model system for studying vascular aging. Mechanisms of Ageing and Development 01/1989; 46(1-3):111-23., DOI:10.1016/0047-6374(88)90119-4

Toru Imamura, Yoshihito Tokita, Youji Mitsui: Purification of basic FGF receptors from rat brain. Biochemical and Biophysical Research Communications 10/1988; 155(2):583-90., DOI:10.1016/S0006-291X(88)80534-5

Tohru Suzuki, Nobumitsu Koga, Toru Imamura, Youji Mitsui: A Novel growth factor in rat spleen which promotes proliferation of hepatocytes in primary culture. Biochemical and Biophysical Research Communications 07/1988; 153(3):1123-8., DOI:10.1016/S0006-291X(88)81344-5

T Imamura, Y Mitsui: [Progress in angiogenesis research]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 05/1988; 33(4):373-81.

Toru Imamura, Youji Mitsui: Heparan sulfate and heparin as a potentiator or a suppressor of growth of normal and transformed vascular endothelial cells. Experimental Cell Research 10/1987; 172(1-172):92-100., DOI:10.1016/0014-4827(87)90096-6

Y Mitsui, T Imamura, T Ohtsuka: [Tumor-derived growth factors–tumor angiogenic factor]. Nippon rinsho. Japanese journal of clinical medicine 02/1986; 44(1):169-79.

T Imamura, Y Mitsui: [Protein and polypeptide growth factors–endothelial cell-derived growth factor]. Nippon rinsho. Japanese journal of clinical medicine 02/1986; 44(1):64-8.

Toru Imamura, Satoshi Toyoshima, Toshiaki Osawa: Lectin-like molecules on the murine macrophage cell surface. Biochimica et Biophysica Acta 12/1984; 805(3):235-44., DOI:10.1016/0167-4889(84)90078-8

Toru Imamura, Masatoshi Beppu, Tadao Terao, Toshiaki Osawa: Valence-Dependent Internalization of Lectins into Balb/c 3T3 Cells. Cell Structure and Function 01/1981; 6(1):1-10., DOI:10.1247/csf.6.1